The Bible was written some 2000 years ago. The letters to the various churches at that time were there to be read in real-time as they directly addressed the issues of that day. For Christians we believe that the letters can still make an impact in our lives as they can direct our behaviour towards others and how we live our lives in general. Now if we live in Africa currently we see great persecution and often poverty. Much of the Bible refers to such persecution and people can relate to this directly. It speaks to them unequivocally and in fact literally. They can read the text and see how it can apply to them even now. For those in the western world, we live in relative comfort. The letters may be interpreted differently as we live in a different circumstances.
Science has made vast leaps forward in recent decades, especially with the understanding of gender and sexuality. We now understand that their is a difference and in fact gender is not binary. Where is this mentioned in the Bible. Well given that the LGBTQ community may be approximately 5% of the population, a letter to another church would only focus upon the vast majority. Moreover, LGBTQ sexuality was well understood in the Roman culture - or rather lustful relationships, those between people for mere sexual satisfaction, were known. Today we regard LGBTQ relationships as those where love is at the centre as with heterosexual relationships.